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That distinction has become increasingly important as insurers and employers scrutinize the long-term economics of GLP-1 therapies, which can carry annual costs exceeding $10,000 per patient while generating uncertainty around sustained adherence rates and long-term reimbursement models

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Structured Titration That Manages Side Effects Properly The GI side effects of semaglutide are largely titration-rate dependent

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doi: 10.1152/jn.00207.2001